Ontology highlight
ABSTRACT:
SUBMITTER: Lehto A
PROVIDER: S-EPMC9546981 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Lehto Alina A Koch Konrad K Barnstorf-Brandes Johanna J Viel Christian C Fuchs Marius M Klein Jochen J
Neurochemical research 20220608 11
ß-Hydroxybutyrate (BHB) is a ketone body formed in high amounts during lipolysis and fasting. Ketone bodies and the ketogenic diet were suggested as neuroprotective agents in neurodegenerative disease. In the present work, we induced transient ischemia in mouse brain by unilaterally occluding the middle cerebral artery for 90 min. BHB (30 mg/kg), given immediately after reperfusion, significantly improved the neurological score determined after 24 h. In isolated mitochondria from mouse brain, ox ...[more]