Comparisons of resting-state brain activity between insomnia and schizophrenia: a coordinate-based meta-analysis.

ABSTRACT: Growing evidence shows that insomnia is closely associated with schizophrenia (SCZ), but the neural mechanism under the association remains unclear. A direct comparison of the patterns of resting-state brain activities would help understand the above question. Using meta-analytic approach, 11 studies of insomnia vs. healthy controls (HC) and 39 studies of SCZ vs. HC were included to illuminate the common and distinct patterns between insomnia and SCZ. Results showed that SCZ and insomnia shared increased resting-state brain activities in frontolimbic structures including the right medial prefrontal gyrus (mPFC) and left parahippocampal gyrus. SCZ additionally revealed greater increased activities in subcortical areas including bilateral putamen, caudate and right insula and greater decreas

SUBMITTER: Gao Z 

PROVIDER: S-EPMC9547062 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature