Prevalence and Incidence of Nonmotor Symptoms in Individuals with and Without Parkinson's Disease.

ABSTRACT:

Background

The prevalence ratio (PR) and incidence rate ratio (IRR) of nonmotor symptoms (NMS) were calculated for early Parkinson's disease (PD) versus non-PD from 2 observational studies.

Methods

NMS were assessed through the self-reported Non-Motor Symptom Questionnaire in the online Fox Insight study and through self- and clinician-rated scales in the Parkinson's Progression Marker Initiative (PPMI) study. Age- and sex-adjusted/matched PR and IRR were estimated for each NMS by PD status using Poisson regression.

Results

Most NMS occurred more frequently in PD. Among 15,194 Fox Insight participants, sexual dysfunction had the largest adjusted PR (12.4 [95% CI, 6.9-22.2]) and dysgeusia/hyposmia had the largest adjusted IRR over a 2-year median follow-up (17.0 [95% C

SUBMITTER: Paracha M 

PROVIDER: S-EPMC9547141 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature