Differential expression of DNA damage repair genes after chemoradiotherapy and inhibition rate in different bladder cancer cells.

ABSTRACT:

Background

To investigate the potential mechanisms of chemoradiotherapy resistance in patients with bladder cancer.

Methods

We assessed three bladder cancer cell lines (5637, J82, and TCCSUP) for their sensitivity to chemoradiotherapy. Reverse transcription quantitative PCR (RT-qPCR) was used to detect the expression of specific genes after chemoradiotherapy or combined with olaparib. The Genome Cancer Atlas (TGCA) database was used to analyze possible radioresistance-related genes and the relationship between their expression and bladder cancer survival and prognostic indicators.

Results

The 5637 cell line showed the most significant sensitivity to chemoradiotherapy. The expression levels of DNA damage repair genes in 5637 cells did not significantly change after che

SUBMITTER: Sun S 

PROVIDER: S-EPMC9547156 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature