The efficacy of anastrozole in subfertile men with and without abnormal testosterone to estradiol ratios.

ABSTRACT:

Background

Aromatase inhibitors (AIs), such as anastrozole, have shown effectiveness in treating oligoasthenozoospermia due to abnormal testosterone to estradiol (T/E₂) ratio (T/E₂ <10). However, its efficacy in subfertile men without abnormal T/E₂ ratio (T/E₂ >10) remained unevaluated. This retrospective study aimed to investigate whether patients with T/E₂ ratio >10 could also benefit from anastrozole treatment.

Methods

One hundred and five subfertile patients treated with 1 mg anastrozole daily were included, in which 62 patients had a T/E₂ ratio of <10, and 43 patients had this ratio >10. Semen parameters and sex hormone levels (including FSH, LH, PRL, E₂ and total T) were measured before and af

SUBMITTER: Yang Y 

PROVIDER: S-EPMC9547167 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature