Combatting antimicrobial resistance via the cysteine biosynthesis pathway in bacterial pathogens.

ABSTRACT: Antibiotics are the cornerstone of modern medicine and agriculture, and rising antibiotic resistance is one the biggest threats to global health and food security. Identifying new and different druggable targets for the development of new antibiotics is absolutely crucial to overcome resistance. Adjuvant strategies that either enhance the activity of existing antibiotics or improve clearance by the host immune system provide another mechanism to combat antibiotic resistance. Targeting a combination of essential and non-essential enzymes that play key roles in bacterial metabolism is a promising strategy to develop new antimicrobials and adjuvants, respectively. The enzymatic synthesis of L-cysteine is one such strategy. Cysteine plays a key role in proteins and is crucial for the synthesis

SUBMITTER: Hicks JL 

PROVIDER: S-EPMC9547175 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature