Synthesis of 1,2,3-triazole-thymol derivatives as potential antimicrobial agents.

ABSTRACT:

Background

Thymol as a natural biological template can be modified chemically since the hydroxyl group makes it a candidate for structural modification. Thus, this study incorporated the triazole moiety on thymol and the chlorination of thymol moiety to help improve its biological potency.

Materials and methods

A series of ten 1,2,3-triazole-thymol derivatives 1-10 were synthesized from thymol, by a click reaction between O-propargyl terminal alkyne of thymol and its chlorothymol with benzyl azide and substituted benzyl azides. Their structures were confirmed by spectroscopic methods (¹H-NMR, ¹³C-NMR, IR, GC-MS-EI/CI and LC-ESI-QTOF-MS). The Well diffusion method using Müeller-Hinton agar plates was used to demonstrate the antimicrobial activitie

SUBMITTER: Addo JK 

PROVIDER: S-EPMC9547220 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature