Identification of candidate biomarkers for severe adenovirus community-acquired pneumonia by proteomic approach.

ABSTRACT:

Introduction

Worldwide, Human adenoviruses (ADV) cause a significant portion of childhood mortality. The severity of ADV Community-acquired Pneumonia (CAP) can be assessed by clinical features, but the rapid and accurate diagnostic biomarkers are still lacking. Candidate biomarkers for severe ADV CAP are to be screened and the different protein expression levels associated with pediatric ADV CAP may help assess the severity of ADV CAP for the pediatricians to make early intervention.

Methods

In our study, serum samples from healthy controls, patients with ADV CAP, streptococcus pneumonia (SP) and respiratory syncytial virus (RSV) infection were collected. Differently expressed proteins (DEPs) were detected by iTRAQ-based mass spectrometry. Gene Ontology and Pathway Enrichmen

SUBMITTER: Shi T 

PROVIDER: S-EPMC9547224 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature