Upregulation of TMCO3 Promoting Tumor Progression and Contributing to the Poor Prognosis of Hepatocellular Carcinoma.

ABSTRACT:

Background and aims

TMCO3, a member of the monovalent cation:proton antiporter-2 family, has been annotated as a Na⁺/H⁺ antiporter, but its pathophysiological role is still unclear. We aimed to investigate the expression profile, prognostic significance, and oncogenic role of TMCO3 in hepatocellular carcinoma (HCC).

Methods

Bioinformatic analyses were conducted using transcriptome data from public databases to determine the expression, prognosis, and functional enrichment of TMCO3 in HCC. TMCO3 expression was further validated in an independent HCC cohort from our institution. The oncogenic role of TMCO3 in HCC was evaluated using in vitro and in vivo experiments.

Results

The upregulated expression of TMCO3 was identified and verifi

SUBMITTER: Dai T 

PROVIDER: S-EPMC9547258 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature