Anatomically and physiologically informed computational model of hepatic contrast perfusion for virtual imaging trials.

ABSTRACT:

Purpose

Virtual (in silico) imaging trials (VITs), involving computerized phantoms and models of the imaging process, provide a modern alternative to clinical imaging trials. VITs are faster, safer, and enable otherwise-impossible investigations. Current phantoms used in VITs are limited in their ability to model functional behavior such as contrast perfusion which is an important determinant of dose and image quality in CT imaging. In our prior work with the XCAT computational phantoms, we determined and modeled inter-organ (organ to organ) intravenous contrast concentration as a function of time from injection. However, intra-organ concentration, heterogeneous distribution within a given organ, was not pursued. We extend our methods in this work to model intra-organ concentration

SUBMITTER: Sauer TJ 

PROVIDER: S-EPMC9547339 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature