Characterization of sepsis inflammatory endotypes using circulatory proteins in patients with severe infection: a prospective cohort study.

ABSTRACT:

Background

Sepsis is a heterogeneous syndrome due to a variable range of dysregulated processes in the host immune response. Efforts are made to stratify patients for personalized immune-based treatments and better prognostic prediction. Using gene expression data, different inflammatory profiles have been identified. However, it remains unknown whether these endotypes mirror inflammatory proteome profiling, which would be more feasible to assess in clinical practice. We aim to identify different inflammatory endotypes based on circulating proteins in a cohort of moderately ill patients with severe infection (Sepsis-2 criteria).

Methods

In this prospective study, 92 inflammatory plasma markers were profiled using a targeted proteome platform and compared between patients wit

SUBMITTER: Ricano-Ponce I 

PROVIDER: S-EPMC9547371 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature