Kruppel-like factor 7 deficiency causes autistic-like behavior in mice via regulating Clock gene.

ABSTRACT:

Background

Krüppel-like factor 7 (klf7), a transcription factor in the nervous system to regulate cell proliferation and differentiation, has been recently identified as a causal gene for autism spectrum disorder (ASD), but the mechanism behind remains unknown.

Result

To uncover this mechanism, in this study we characterized the involvement of klf7 in circadian rhythm by knocking down klf7 in N2A cells and examining the rhythmic expression of circadian genes, especially Clock gene. We constructed klf7^-/- mice and then investigated into klf7 regulation on the expression of rhythm genes in vivo as well as the use of melatonin to rescue the autism behavior. Our results illustrated that circadian rhythm was disrupted in klf7 knockdown cells and that klf7^-/-

SUBMITTER: Tian H 

PROVIDER: S-EPMC9547400 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature