Potential novel biomarkers in small intestine for obesity/obesity resistance revealed by multi-omics analysis.

ABSTRACT:

Background

Although obesity is caused by different factors, individual susceptibility to obesity differs among people under the same circumstances. The microbiota in the caecum or fresh faeces and metabolites in blood or urine contribute to obesity resistance; however, the microbiota or metabolites in the small intestine have not been extensively studied.

Methods

To investigate the relationship between the microbiota or metabolites in the small intestine and susceptibility to obesity, eighty-eight male C57BL/6 mice were fed a high-fat diet (HFD) for 8 weeks to establish two models of obesity and obesity resistance. For further study, six mice were chosen from among the obesity models, and twelve mice were randomly chosen from among the obesity resistance models. After fastin

SUBMITTER: Pang Y 

PROVIDER: S-EPMC9547412 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature