Oral anticoagulants in patients with atrial fibrillation at low stroke risk: a multicentre observational study.

ABSTRACT:

Aims

There is currently no consensus on whether atrial fibrillation (AF) patients at low risk for stroke (one non-sex-related CHA2DS2-VASc point) should be treated with an oral anticoagulant.

Methods and results

We conducted a multi-country cohort study in Sweden, Denmark, Norway, and Scotland. In total, 59 076 patients diagnosed with AF at low stroke risk were included. We assessed the rates of stroke or major bleeding during treatment with a non-vitamin K antagonist oral anticoagulant (NOAC), a vitamin K antagonist (VKA), or no treatment, using inverse probability of treatment weighted (IPTW) Cox regression. In untreated patients, the rate for ischaemic stroke was 0.70 per 100 person-years and the rate for a bleed was also 0.70 per 100 person-years. Comparing NOAC with no

SUBMITTER: Komen JJ 

PROVIDER: S-EPMC9547505 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature