Antiretroviral Drug Resistance in HIV Sequences From People Who Inject Drugs and Men Who Have Sex With Men Across 21 Cities in India.

ABSTRACT:

Background

Drug resistance testing is limited in public-sector human immunodeficiency virus (HIV) care in India, and there are few systematic samplings for prevalent drug resistance mutations (DRMs), particularly among men who have sex with men (MSM) and people who inject drugs (PWID).

Methods

We conducted genotypic resistance testing on 915 HIV sequences sampled from viremic self-reported antiretroviral therapy (ART) experienced and naive PWID and MSM recruited from 21 cities across India in 2016-2017. We analyzed factors associated with resistance using logistic regression and evaluated evidence for transmitted resistance using phylogenetic analyses.

Results

Of the 915 participants sequenced, median age was 31, 436 were MSM, and 191 were ART experienced. Overall, 62

SUBMITTER: Clipman SJ 

PROVIDER: S-EPMC9547506 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature