Recent Updates on the Development of Deuterium-Containing Drugs for the Treatment of Cancer

ABSTRACT: Abstract Cancer is one of the deadliest diseases in the world. In 2020, 19.3 million cancer cases and 10 million deaths were reported in the world. It is supposed that the prevalence of cancer cases will rise to 28.4 million by 2040. Chemotherapy-based regimens have a narrow therapeutic index, severe adverse drug reactions, and lack metabolic stability. Besides, the metabolism of anticancer produces several non-active and toxic metabolites that reduce exposure of the target site to the parent drug. Therefore, developing better-tolerated and effective new anticancer drugs and modification of the existing anticancer drugs to minimize toxicity and increase efficacy has become a very urgent need. Deuterium incorporation reduces the metabolism of certain drugs that are breakdown by pathways inv

SUBMITTER: Belete T 

PROVIDER: S-EPMC9547620 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature