Identification of biomarkers related to tumorigenesis and prognosis in breast cancer.

ABSTRACT:

Background

The aim of the present study was to identify the central genes and prognostic index of breast cancer, and to determine the relationship between prognostic index and immune infiltration levels to provide useful information for the diagnosis and treatment of breast cancer.

Methods

The Cancer Genome Atlas breast cancer dataset and 2 microarray datasets were applied to screen overlapping differentially expressed genes (DEGs) between breast cancer tissue and normal breast tissue samples. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were conducted through the Database for Annotation, Visualization, and Integrated Discovery. Protein-protein interaction (PPI) networks were used to screen hub genes of the overlapping DEGs. Gene Expression Profiling In

SUBMITTER: Paizula X 

PROVIDER: S-EPMC9547705 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature