LGALS2 suppresses the progression of papillary thyroid carcinoma by regulating the PI3K/AKT pathway

ABSTRACT:

Background

The galectin 2 (LGALS2) protein has been shown to be associated with the pathogenic progression of a range of cancer types, yet its role in papillary thyroid carcinoma (PTC) remains poorly defined. Accordingly, the present study was conducted to address this gap in the literature.

Methods

Eighty pairs of tumor and paracancerous tissues from PTC patients were collected. Western immunoblotting and real-time quantitative polymerase chain reaction (qPCR) were used to compare LGALS2 expression levels in tumor and paracancerous tissues from PTC patients. An LGALS2 overexpression construct was produced by inserting the coding sequence for this gene into a pcDNA4.0 vector, and LGALS2-specific and control siRNA constructs were obtained. CCK-8, EdU uptake, and apoptotic

SUBMITTER: Xu D 

PROVIDER: S-EPMC9547712 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature