Recent advances in the application of microbial diamine oxidases and other histamine-oxidizing enzymes.

ABSTRACT: The consumption of foods fraught with histamine can lead to various allergy-like symptoms if the histamine is not sufficiently degraded in the human body. The degradation occurs primarily in the small intestine, naturally catalyzed by the human diamine oxidase (DAO). An inherent or acquired deficiency in human DAO function causes the accumulation of histamine and subsequent intrusion of histamine into the bloodstream. The histamine exerts its effects acting on different histamine receptors all over the body but also directly in the intestinal lumen. The inability to degrade sufficient amounts of dietary histamine is known as the 'histamine intolerance'. It would be preferable to solve this problem initially by the production of histamine-free or -reduced foods and by the oral supplementati

SUBMITTER: Kettner L 

PROVIDER: S-EPMC9547800 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature