Lipoprotein(a) in systemic lupus erythematosus is associated with history of proteinuria and reduced renal function.

ABSTRACT:

Objective

Proteinuria is the clinical expression of lupus nephritis and despite recent advances in the therapeutic armamentarium for lupus nephritis, morbidity and mortality rates remain high. Therefore, the identification of factors that predict lupus nephritis is paramount in preventing damage accrual and disease progression. Lipoprotein (a) (Lp[a]) is a primarily genetically inherited plasma lipoprotein with pro-thrombotic and pro-atherosclerotic effects. Elevated Lp(a) has been observed at early stages of renal impairment in the general population and is associated with the development of chronic kidney disease. However, little is known about renal implications of Lp(a) in SLE. Thus, we evaluated Lp(a) and atherosclerotic events, thrombotic events, renal disease, and disease ac

SUBMITTER: Connolly CM 

PROVIDER: S-EPMC9547824 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature