Endotyping pediatric obesity-related asthma: Contribution of anthropometrics, metabolism, nutrients, and CD4⁺ lymphocytes to pulmonary function.

ABSTRACT:

Background

Obesity-related complications including visceral fat, metabolic abnormalities, nutrient deficiencies, and immune perturbations are interdependent but have been individually associated with childhood asthma.

Objective

We sought to endotype childhood obesity-related asthma by quantifying contributions of obesity-related complications to symptoms and pulmonary function.

Methods

Multiomics analysis using Similarity Network Fusion followed by mediation analysis were performed to quantify prediction of obese asthma phenotype by different combinations of anthropometric, metabolic, nutrient, and T_H-cell transcriptome and DNA methylome data sets.

Results

Two clusters (n = 28 and 26) distinct in their anthropometric (neck and midarm circumference, w

SUBMITTER: Thompson D 

PROVIDER: S-EPMC9547831 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature