Perioperative Coagulation Changes in Total Pancreatectomy and Islet Autotransplantation.

ABSTRACT:

Objectives

Thrombotic complications after total pancreatectomy with islet autotransplantation (TPIAT) are common. However, the systemic changes to coagulation in the perioperative period have not been well studied. Our objective was to evaluate the derangements in coagulation in the perioperative period for this procedure.

Methods

This was a prospective observational study of patients undergoing elective TPIAT for chronic pancreatitis. Multiple methods of evaluating coagulation, including 2 viscoelastic assays and standard laboratory assays were obtained at defined intraoperative and postoperative intervals.

Results

Fifteen patients were enrolled. Laboratory values demonstrated initial intraoperative hypercoagulability before significant systemic anticoagulation after

SUBMITTER: Bergman ZR 

PROVIDER: S-EPMC9547836 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature