Within-eye and between-subject variability for reflectance of the retinal nerve fibre layer.

ABSTRACT:

Purpose

Reflectance of retinal nerve fibre layer (RNFL) can contribute to detecting the presence of glaucomatous damage and defining its extent. As a step towards developing a normative database for RNFL reflectance, we assessed within-eye and between-subject variability for RNFL reflectance in healthy eyes.

Methods

Vertical 30° × 15° volume scans at the optic disc were gathered using SD-OCT (Spectralis OCT) from people free of eye disease. Scans were gathered for both eyes of 30 younger adults (mean ± SD = 27 ± 3 years) and for one eye of 30 older adults (68 ± 8 years). Reflectance was quantified for each voxel as the depth-resolved attenuation coefficient (AC). Values for AC were extracted for four slabs (0-52, 24-52, 24-36 and 36-60 μm) and at depths from 24 to 60 μm belo

SUBMITTER: Cheung H 

PROVIDER: S-EPMC9547838 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature