Alterations in a cross-hemispheric circuit associates with novelty discrimination deficits in mouse models of neurodegeneration.

ABSTRACT: A major pathological hallmark of neurodegenerative diseases, including Alzheimer's, is a significant reduction in the white matter connecting the two cerebral hemispheres, as well as in the correlated activity between anatomically corresponding bilateral brain areas. However, the underlying circuit mechanisms and the cognitive relevance of cross-hemispheric (CH) communication remain poorly understood. Here, we show that novelty discrimination behavior activates CH neurons and enhances homotopic synchronized neural oscillations in the visual cortex. CH neurons provide excitatory drive required for synchronous neural oscillations between hemispheres, and unilateral inhibition of the CH circuit is sufficient to impair synchronous oscillations and novelty discrimination behavior. In the 5XFAD

SUBMITTER: Adaikkan C 

PROVIDER: S-EPMC9547933 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature