Optical genome mapping identifies clinically relevant genomic rearrangements in prostate cancer biopsy sample.

ABSTRACT:

Background

Prostate cancer (PCa) is characterized by complex genomic rearrangements such as the ETS oncogene family fusions, yet the clinical relevance is not well established. While paneled genetic tests of DNA repair genes are recommended in advanced PCa, conventional genomic or cytogenetic tools are not ideal for genome-wide screening of structural variations (SVs) such as balanced translocation due to cost and/or resolution issues.

Methods

In this study, we tested the feasibility of whole-genome optical genomic mapping (OGM), a newly developed platform for genome-wide SV analysis to detect complex genomic rearrangements in consecutive unselected PCa samples from MRI/US-fusion targeted biopsy.

Results

We tested ten samples, and nine (90%) passed quality check. Aver

SUBMITTER: Shim Y 

PROVIDER: S-EPMC9548106 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature