Chromosome-level assemblies from diverse clades reveal limited structural and gene content variation in the genome of Candida glabrata.

ABSTRACT:

Background

Candida glabrata is an opportunistic yeast pathogen thought to have a large genetic and phenotypic diversity and a highly plastic genome. However, the lack of chromosome-level genome assemblies representing this diversity limits our ability to accurately establish how chromosomal structure and gene content vary across strains.

Results

Here, we expanded publicly available assemblies by using long-read sequencing technologies in twelve diverse strains, obtaining a final set of twenty-one chromosome-level genomes spanning the known C. glabrata diversity. Using comparative approaches, we inferred variation in chromosome structure and determined the pan-genome, including an analysis of the adhesin gene repertoire. Our analysis uncovered four new adhesin orthogroups and

SUBMITTER: Marcet-Houben M 

PROVIDER: S-EPMC9548116 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature