Characterization of placental and decidual cell development in early pregnancy loss by single-cell RNA sequencing.

ABSTRACT:

Background

Early pregnancy loss (EPL) presents as sporadic or recurrent miscarriage during the first trimester. In addition to chromosomal defects, EPL may result from impairment of the placental-decidual interface at early gestational age due to gene-environmental interactions.

Methods

To better understand the pathogenesis associated with this impairment, cell development in chorionic villi and decidua of different forms of EPL (sporadic or recurrent) was investigated with single-cell RNA sequencing and compared to that of normal first-trimester tissue.

Results

Unique gene expression signatures were obtained for the different forms of EPL and for normal tissue and the composition of placental and decidual cell clusters in each form was established. In particular, the

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC9548121 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature