Dietary-derived vitamin B12 protects Caenorhabditis elegans from thiol-reducing agents.

ABSTRACT:

Background

One-carbon metabolism, which includes the folate and methionine cycles, involves the transfer of methyl groups which are then utilised as a part of multiple physiological processes including redox defence. During the methionine cycle, the vitamin B12-dependent enzyme methionine synthetase converts homocysteine to methionine. The enzyme S-adenosylmethionine (SAM) synthetase then uses methionine in the production of the reactive methyl carrier SAM. SAM-binding methyltransferases then utilise SAM as a cofactor to methylate proteins, small molecules, lipids, and nucleic acids.

Results

We describe a novel SAM methyltransferase, RIPS-1, which was the single gene identified from forward genetic screens in Caenorhabditis elegans looking for resistance to lethal concentrat

SUBMITTER: Winter AD 

PROVIDER: S-EPMC9548181 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature