Pivotal interplays between fecal metabolome and gut microbiome reveal functional signatures in cerebral ischemic stroke.

ABSTRACT:

Background

Integrative analysis approaches of metagenomics and metabolomics have been widely developed to understand the association between disease and the gut microbiome. However, the different profiling patterns of different metabolic samples in the association analysis make it a matter of concern which type of sample is the most closely associated with gut microbes and disease. To address this lack of knowledge, we investigated the association between the gut microbiome and metabolomic profiles of stool, urine, and plasma samples from ischemic stroke patients and healthy subjects.

Methods

We performed metagenomic sequencing (feces) and untargeted metabolomics analysis (feces, plasma, and urine) from ischemic stroke patients and healthy volunteers. Differential analyses w

SUBMITTER: Zhao L 

PROVIDER: S-EPMC9548195 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature