Neurophysiological correlates of memory change in children with fetal alcohol spectrum disorders treated with choline.

ABSTRACT:

Background

Prenatal and early postnatal choline supplementation reduces cognitive and behavioral deficits in animal models of Fetal Alcohol Spectrum Disorder (FASD). In a previously published 9-month clinical trial of choline supplementation in children with FASD, we reported that postnatal choline was associated with improved performance on a hippocampal-dependent recognition memory task. The current paper describes the neurophysiological correlates of that memory performance for trial completers.

Methods

Children with FASD (N = 24) who were enrolled in a clinical trial of choline supplementation were followed for 9 months. Delayed recall on a 9-step elicited imitation task (EI) served as the behavioral measure of recognition memory. Neurophysiological correlates of

SUBMITTER: Fuglestad AJ 

PROVIDER: S-EPMC9548619 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature