The IL-20RB receptor and the IL-20 signaling pathway in regulating host defense in oral mucosal candidiasis.

ABSTRACT: Pseudomembranous candidiasis (thrush), erythematous candidiasis, and fungal esophagitis are infections of the barrier mucosa of the upper gastrointestinal tract. The majority of these infections are caused by Candida albicans, an opportunistic fungal pathogen that frequently exists as a harmless commensal on mucosal surfaces lining the gastrointestinal tract. Oral infections are initiated in the superficial stratified squamous epithelium, in which keratinocytes are the most abundant host cells and are the initial points of contact with C. albicans present in saliva. Intrinsic features of oral keratinocytes are likely to play important roles in host defense and tissue homeostasis in oral candidiasis. One understudied pathway that may be important for modulating oral candidiasi

SUBMITTER: Beute JE 

PROVIDER: S-EPMC9548646 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature