Causal relationship between tea intake and cardiovascular diseases: A Mendelian randomization study.

ABSTRACT:

Background

Although studies suggest that tea consumption is associated with a reduced risk of cardiovascular disease (CVD). There is no unified conclusion about the potential relationship between tea drinking and CVD. We used a two-sample Mendelian randomized (MR) analysis to systematically explore the causal relationship between tea intake and CVD subtypes for the first time. Furthermore the mediating effect of hypertension was also explored by a two-step MR.

Methods

Genetic instruments for tea intake were identified from a genome-wide association studies (GWAS) involving 447,485 people. Summary data on cardio-vascular disease came from different GWAS meta-analysis studies. In the first step we explored the causal effect of tea intake and CVD. In the second step, we examine

SUBMITTER: Gao N 

PROVIDER: S-EPMC9548982 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature