A risk-based approach to measuring population micronutrient status from blood biomarker concentrations.

ABSTRACT:

Background

Nutrient biomarkers and their definitive cut-offs are used to classify individuals as nutrient-deficient or sufficient. This determinism does not consider any uncertainty, and a probability approach, using biomarker distributions, is then preferable to define the risk of nutrition deficiency when in populations.

Method

Healthy 1-19-year-old children and adolescents were selected from the Comprehensive National Nutrition Survey (CNNS), to obtain probability distributions of their retinol, zinc and vitamin B₁₂, along with erythrocyte folate. Model-based estimates of location, scale and shape parameters of these distributions were obtained across ages. Subsequently, in the entire sample of 1-19 year old children of CNNS, the population risk of deficiency (

SUBMITTER: Ghosh S 

PROVIDER: S-EPMC9548994 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature