Interpreting Breast Cancer Mortality Trends Related to Introduction of Mammography Screening: A Simulation Study.

ABSTRACT: Background. Several studies have evaluated the effect of mammography screening on breast cancer mortality based on overall breast cancer mortality trends, with varied conclusions. The statistical power of such trend analyses is, however, not carefully studied. Methods. We estimated how the effect of screening on overall breast cancer mortality is likely to unfold. Because a screening effect is based on earlier treatment, screening can affect only new incident cases after screening introduction. To evaluate the likelihood of detecting screening effects on overall breast cancer mortality time trends, we calculated the statistical power of joinpoint regression analysis on breast cancer mortality trends around screening introduction using simulations. Results. We found tha

SUBMITTER: Heggland T 

PROVIDER: S-EPMC9549205 | biostudies-literature | 2022 Jul-Dec

REPOSITORIES: biostudies-literature