Selective miRNA inhibition in CD8⁺ cytotoxic T lymphocytes enhances HIV-1 specific cytotoxic responses.

ABSTRACT: miRNAs dictate relevant virus-host interactions, offering new avenues for interventions to achieve an HIV remission. We aimed to enhance HIV-specific cytotoxic responses-a hallmark of natural HIV control- by miRNA modulation in T cells. We recruited 12 participants six elite controllers and six patients with chronic HIV infection on long-term antiretroviral therapy ("progressors"). Elite controllers exhibited stronger HIV-specific cytotoxic responses than the progressors, and their CD8+T cells showed a miRNA (hsa-miR-10a-5p) significantly downregulated. When we transfected ex vivo CD8⁺ T cells from progressors with a synthetic miR-10a-5p inhibitor, miR-10a-5p levels decreased in 4 out of 6 progressors, correlating with an increase in HIV-specific cytotoxic responses. The

SUBMITTER: Madrid-Elena N 

PROVIDER: S-EPMC9549323 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature