Prognostic value of long-term antidiabetic and antihypertensive therapy in postoperative gastric cancer patients: the FIESTA study

ABSTRACT:

Background

Gastric cancer is often comorbid with hypertension and diabetes mellitus and increases the mortality risk.

Materials and methods

We conducted this prospective cohort study to investigate antidiabetics and antihypertensives’ impact on gastric cancer survival. 3012 patients with gastric carcinoma undergoing radical gastrectomy were enrolled since January 2000 and followed up until July 2020.

Results

Hypertension and diabetes patients had worse survival than patients without hypertension and diabetes [median survival time (MST): 48 versus 112.5 months, p < 0.001 for hypertension, MST: 32.7 versus 183+ months, p < 0.001 for diabetes]. Compared to untreated patients, treated patients had better survival (MST: 109.7 months versus 39.1 months, p < 0.001 for a

SUBMITTER: Wang L 

PROVIDER: S-EPMC9549639 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature