Serum phosphorylated tau protein 181 and neurofilament light chain in cognitively impaired heart failure patients.

ABSTRACT:

Background

Chronic heart failure (HF) is known to increase the risk of developing Alzheimer's dementia significantly. Thus, detecting and preventing mild cognitive impairment, which is common in patients with HF, is of great importance. Serum biomarkers are increasingly used in neurological disorders for diagnostics, monitoring, and prognostication of disease course. It remains unclear if neuronal biomarkers may help detect cognitive impairment in this high-risk population. Also, the influence of chronic HF and concomitant renal dysfunction on these biomarkers is not well understood.

Methods

Within the monocentric Cognition.Matters-HF study, we quantified the serum levels of phosphorylated tau protein 181 (pTau) and neurofilament light chain (NfL) of 146 extensively phenotyp

SUBMITTER: Traub J 

PROVIDER: S-EPMC9549648 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature