Cytomegalovirus infection disrupts the influence of short-chain fatty acid producers on Treg/Th17 balance.

ABSTRACT:

Background

Both the gut microbiota and chronic viral infections have profound effects on host immunity, but interactions between these influences have been only superficially explored. Cytomegalovirus (CMV), for example, infects approximately 80% of people globally and drives significant changes in immune cells. Similarly, certain gut-resident bacteria affect T-cell development in mice and nonhuman primates. It is unknown if changes imposed by CMV on the intestinal microbiome contribute to immunologic effects of the infection.

Results

We show that rhesus cytomegalovirus (RhCMV) infection is associated with specific differences in gut microbiota composition, including decreased abundance of Firmicutes, and that the extent of microbial change was associated with immunologic ch

SUBMITTER: Chin N 

PROVIDER: S-EPMC9549678 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature