Sensitivity towards HDAC inhibition is associated with RTK/MAPK pathway activation in gastric cancer.

ABSTRACT: Gastric cancer ranks the fifth most common and third leading cause of cancer-related deaths worldwide. Alterations in the RTK/MAPK, WNT, cell adhesion, TP53, TGFβ, NOTCH, and NFκB signaling pathways could be identified as main oncogenic drivers. A combination of altered pathways can be associated with molecular subtypes of gastric cancer. In order to generate model systems to study the impact of different pathway alterations in a defined genetic background, we generated three murine organoid models: a RAS-activated (Kras^G12D , Tp53^R172H ), a WNT-activated (Apc^fl/fl , Tp53^R172H ), and a diffuse (Cdh1^fl/fl , Apc^fl/fl ) model. These organoid models were morphologically and phenotypically diverse, differed in proteome expression

SUBMITTER: Seidlitz T 

PROVIDER: S-EPMC9549728 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature