In vivo behavior of [⁶⁴Cu]NOTA-terpyridine platinum, a novel chemo-radio-theranostic agent for imaging, and therapy of colorectal cancer.

ABSTRACT: To overcome resistance to chemotherapy for colorectal cancer, we propose to validate in vivo a novel terpyridine-platinum (TP) compound radiolabeled with the radio-theranostic isotope ⁶⁴Cu. In vivo stability, biodistribution, PET imaging, tumor growth delay, toxicity and dosimetry of [⁶⁴Cu]NOTA-C3-TP were determined. The current experimental studies show that [⁶⁴Cu]NOTA-C3-TP is stable in vivo, rapidly eliminated by the kidneys and has a promising tumor uptake ranging from 1.8 ± 0.4 to 3.0 ± 0.2 %ID/g over 48 h. [⁶⁴Cu]NOTA-C3-TP retarded tumor growth by up to 6 ± 2.0 days and improved survival relative to vehicle and non-radioactive [^NatCu]NOTA-C3-TP over 17 days of tumor growth observation. This effect was obtaine

SUBMITTER: Khosravifarsani M 

PROVIDER: S-EPMC9549809 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature