Understanding etiology of community-acquired central nervous system infections using metagenomic next-generation sequencing.

ABSTRACT:

Background

Community-acquired central nervous system infections (CA-CNS infections) have the characteristics of acute onset and rapid progression, and are associated with high levels of morbidity and mortality worldwide. However, there have been only limited studies on the etiology of this infections. Here, metagenomic next-generation sequencing (mNGS), a comprehensive diagnosis method, facilitated us to better understand the etiology of CA-CNS infections.

Methods

We conducted a single-center retrospective study between September 2018 and July 2021 in which 606 cerebrospinal fluid (CSF) samples were collected from suspected CNS infectious patients for mNGS testing, and all positive samples were included in this analysis.

Results

After the exclusion criteria, a total o

SUBMITTER: Zhang S 

PROVIDER: S-EPMC9549810 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature