Old drugs, new tricks: leveraging known compounds to disrupt coronavirus-induced cytokine storm.

ABSTRACT: A major complication in COVID-19 infection consists in the onset of acute respiratory distress fueled by a dysregulation of the host immune network that leads to a run-away cytokine storm. Here, we present an in silico approach that captures the host immune system's complex regulatory dynamics, allowing us to identify and rank candidate drugs and drug pairs that engage with minimal subsets of immune mediators such that their downstream interactions effectively disrupt the signaling cascades driving cytokine storm. Drug-target regulatory interactions are extracted from peer-reviewed literature using automated text-mining for over 5000 compounds associated with COVID-induced cytokine storm and elements of the underlying biology. The targets and mode of action of each compound, as well as com

SUBMITTER: Richman S 

PROVIDER: S-EPMC9549818 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature