Geometry of abstract learned knowledge in the hippocampus.

ABSTRACT: Hippocampal neurons encode physical variables^1-7 such as space¹ or auditory frequency⁶ in cognitive maps⁸. In addition, functional magnetic resonance imaging studies in humans have shown that the hippocampus can also encode more abstract, learned variables^9-11. However, their integration into existing neural representations of physical variables^12,13 is unknown. Here, using two-photon calcium imaging, we show that individual neurons in the dorsal hippocampus jointly encode accumulated evidence with spatial position in mice performing a decision-making task in virtual reality^14-16. Nonlinear dimensionality reduction¹³ showed that population activity was well-described by approximately four to six latent

SUBMITTER: Nieh EH 

PROVIDER: S-EPMC9549979 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature