Credibility assessment of patient-specific computational modeling using patient-specific cardiac modeling as an exemplar

ABSTRACT: Reliable and robust simulation of individual patients using patient-specific models (PSMs) is one of the next frontiers for modeling and simulation (M&S) in healthcare. PSMs, which form the basis of digital twins, can be employed as clinical tools to, for example, assess disease state, predict response to therapy, or optimize therapy. They may also be used to construct virtual cohorts of patients, for in silico evaluation of medical product safety and/or performance. Methods and frameworks have recently been proposed for evaluating the credibility of M&S in healthcare applications. However, such efforts have generally been motivated by models of medical devices or generic patient models; how best to evaluate the credibility of PSMs has largely been unexplored. The aim of this paper is to u

SUBMITTER: Galappaththige S 

PROVIDER: S-EPMC9550052 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature