Diagnostic test accuracy of novel biomarkers for lupus nephritis—An overview of systematic reviews

ABSTRACT:

Introduction

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with multiorgan inflammatory involvement and a mortality rate that is 2.6-fold higher than individuals of the same age and sex in the general population. Approximately 50% of patients with SLE develop renal impairment (lupus nephritis). Delayed diagnosis of lupus nephritis is associated with a higher risk of progression to end-stage renal disease, the need for replacement therapy, and mortality. The initial clinical manifestations of lupus nephritis are often discrete or absent and are usually detected through complementary tests. Although widely used in clinical practice, their accuracy is limited. A great scientific effort has been exerted towards searching for new, more sensitive, and specific bioma

SUBMITTER: Guimaraes J 

PROVIDER: S-EPMC9550089 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature