Identification and validation of prognostic autophagy-related genes associated with immune microenvironment in human gastric cancer.

ABSTRACT: Autophagy-related genes (ATGs) play critical roles in tumorigenesis and progression in gastric cancer (GC). The present study aimed to identify immune-based prognostic ATGs and verify their functions in tumor immune microenvironment (TIME) in GC. Macrophage infiltration was found to negatively correlate with prognosis in GC patients. After stratifying by infiltration levels of macrophages, we screened The Cancer Genome Atlas and Human Autophagy Database to identify the differentially expressed ATGs (DE-ATGs). Of 1,433 differentially expressed genes between the two groups, seven genes qualified as DE-ATGs. Of these, CXCR4, DLC1, and MAP1LC3C, exhibited strong prognostic prediction ability in Kaplan-Meier survival-log-rank test. High expression of these genes correlated

SUBMITTER: Tian R 

PROVIDER: S-EPMC9550254 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature