Teleost fish IgM⁺ plasma-like cells possess IgM-secreting, phagocytic, and antigen-presenting capacities.

ABSTRACT: Plasma cells are terminally differentiated antibody-secreting B lymphocytes that contribute to humoral immunity by producing large numbers of antibodies. Increasing evidence suggests that teleost fish B cells share certain characteristics with mammalian B1 B cells, including antibody-secreting, phagocytic, and antigen-presenting capacities. However, the difference between mature B cells and plasma cells remains unclear. In this study, we found that, based on their light-scattering characteristics, tilapia anterior kidney (AK) leukocytes can be categorized into two IgM⁺ B-cell subsets: the lymphoid (L) gate and granulocyte-monocyte/macrophage (G-M) subsets. G-M gate cells are more numerous than L-gate cells and have higher mean fluorescence, but lower forward scatter and side sca

SUBMITTER: Wu L 

PROVIDER: S-EPMC9550268 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature