Differentially Expressed Genes Study Shown Potential for BCG Stimulation in Reducing the Severity of COVID-19.

ABSTRACT: The incidence of COVID-19 infection and death is known to be lower in tuberculosis (TB) endemic countries than in nonendemic countries. The Bacillus Calmette-Guerin (BCG) vaccination, which is commonly administered in TB endemic countries, was previously reported to have a nonspecific protective effect against several infections, including COVID-19. In this study, we used a differentially expressed genes (DEG) approach to analyze the genes modulated by BCG vaccination and COVID-19 infection. The Gene Expression Omnibus (GEO) database was used to select a COVID-19 gene expression data set with GSE164805, GSE14408, and GSE58636, and DEG in each data set were identified using the GEO2R online tools and selected using the adjusted p value (padj) 0.05 criteria. The protein-protein intera

SUBMITTER: Pratomo IP 

PROVIDER: S-EPMC9550501 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature