[Nur77 promotes invasion and migration of gastric cancer cells through the NF-κB/IL-6 pathway].

ABSTRACT:

Objective

To analyze the association of Nur77 with overall survival of gastric cancer patients and investigate the role of Nur77 in invasion and migration of gastric cancer cells.

Methods

Oncomine database was used to analyze the expression of Nur77 in gastric cancer and gastric mucosa tissues, and the distribution characteristics of Nur77 protein between gastric cancer and normal tissues were compared using Human Protein Atlas. GEPIA2 was used to analyze the relationship of Nur77 expression and the patients' survival. The expression of Nur77 in gastric cancer cell lines GES-1, AGS and MKN-45 were detected by Western blotting. The regulatory interactions between IL-6 and Nur77 were verified by transfecting the cells with specific Nur-77 siRNA and Nur-77-overexpressing plasmi

SUBMITTER: Li W 

PROVIDER: S-EPMC9550556 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature