Circular RNAs as prognostic and diagnostic biomarkers in renal cell carcinoma.

ABSTRACT:

Background

Circular RNAs (circRNAs) play pivotal roles in proliferation, apoptosis, migration, and invasion of renal cell carcinoma (RCC) cells. This study is aimed to systematically summarize the current evidence regarding the clinical implications of circRNAs in RCC patients.

Methods

A systematic search in PubMed, Embase, and Web of Science was performed until January 1, 2022. The correlation between the expression of circRNAs and clinicopathological, prognostic, and diagnostic features of RCC was evaluated using the meta-analysis.

Results

Ultimately, 41 studies with 3485 RCC patients were included in this study: 26 studies for clinicopathological features, 31 studies for prognosis, and eight studies for diagnosis. Altered expression of circRNAs was significantly as

SUBMITTER: Rashedi S 

PROVIDER: S-EPMC9550963 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature